Llanidloes Town are aiming for a place in the last eight of the Central Wales Cup.
The runaway MMP Mid Wales League leaders welcome Penparcau and will be aiming for a place in the quarter-finals alongside fellow Division One sides Berriew, Welshpool Town and Montgomery.
Waterloo Rovers will be hoping to upset the odds when they welcome neighbours Guilsfield for a Central Wales Cup fourth round derby.
Guilsfield are the in-form team in the JD Cymru North, sitting third in the table, but Waterloo will be hoping home advantage will help.
Llanfair United will be looking to build on last week’s first win of the season when they continue their JD Cymru North survival fight against Llandudno. Llanrhaeadr welcome Colwyn Bay.
Elsewhere, there is action in the MMP and JT Hughes leagues.
Central Wales Cup, fourth round
Berriew v Newcastle Emlyn
Bishop’s Castle v Llanilar
Brecon Corries v Tywyn Bryncrug
Llanidloes Town v Penparcau
Montgomery Town v Builth Wells
Waterloo Rovers v Guilsfield
Welshpool Town v Rhayader Town
JD Cymru North
Llanfair United v Llandudno
Llanrhaeadr v Colwyn Bay
MMP Mid Wales League
Division One
Bow Street v Carno
Four Crosses v Llansantffraid Village
Kerry v Llandrindod Wells
Radnor Valley v Aberaeron
Division Two
Churchstoke v Dolgellau
Dyffryn Banw v Aber University
Knighton Town v Abermule
Newbridge-on-Wye v Borth Utd
JT Hughes Montgomeryshire League One
Guilsfield Reserves v Maesyrhandir
Llanfyllin Town v Llanfair United Reserves
Llangedwyn v Llanrhaeadr Reserves
Trewern United v Trefonen
JT Hughes Montgomeryshire League Division Two
Caersws Reserves v Kerry Reserves
Llanymynech v Churchstoke Reserves
Newtown Wanderers v Four Crosses Reserves