Caersws manager Graham Evans made changes for the Huws Gray Alliance trip to Denbigh but his side still lost 3-2.
Tristan Pierce converted a 15th minute penalty for the hosts and Darren Ducket netted twice before Steve Blenkinsop and Luke Sherbon gave the Bluebirds hope
Llanfair kept up the challenge in the Spar Mid Wales League by beating Bow Street 2-1. Llanidloes struggled to beat lowly Machynlleth 2-1.
JD Welsh Premier League
Aberystwyth 3 Newtown 0
Huws Gray Alliance
Guilsfield 2 FC Queens Park 1
Denbigh 3 Caersws 2
Spar Mid Wales League
Division 1
Welshpool 2 Berriew 2
Aberaeron 2 Knighton 1
Carno 5 Kerry 1
Churchstoke 1 Tywyn Bryncrug 2
Llanfair Utd 2 Bow Street 1
Llanidloes 2 Machynlleth 1
Llanrhaeadr 2 Radnor Valley 2