A "ping-demic" could hit local business and essential services, Montgomeryshire's Member of the Senedd has warned.
Russell George, MS for Montgomeryshire, said action needed to be taken to change isolation rules on the Track and Trace app and isolation rules.
He was speaking as Shadow Health Spokesperson for the Conservatives in the Welsh Parliament.
It cam after Transport for Wales issued an apology for cancellations to numerous rail services as Covid-19 notifications forced a number of staff to self-isolate.
Mr George said: “We have made great strides with our vaccination programme and the restoration of many freedoms, but our vital public services and economic recovery could be severely hampered by a potential ‘ping-demic'."
“The sensitivity of the NHS app and isolation rules across the UK need an immediate review as it is somewhat bizarre double-vaccinated individuals, some who’ve also already had COVID, are being forced to isolate.
“The 10-day self-isolation period for people who have received both jabs needs to come to an end, and a system implemented for those not yet fully vaccinated.
“In Wales, this will require a joined-up approach and I implore both the Welsh and UK Governments to work together immediately so changes can be implemented with pace so our recovery does not ground to a halt.”