Newtown face a long Friday night trip to Bangor City in the JD Welsh Premier League.
The Robins will travel in confidence after their stunning 4-2 win over The New Saints last Saturday.
Caersws face a real six pointer against bottom-of-the-table Llandudno Junction while most of the other local clubs are involved in Central Wales cup ties.
Friday
JD Welsh Premier
Bangor v Newtown
Saturday
Huws Gray Alliance
Ruthin v Guilsfield
Caersws v Llandudno Junction
Spar Mid Wales League
Division 1
Aberaeron v Machynlleth
Division 2
Abermule v Talgarth Town
Llansantffraid Village v Dolgellau
Penybont v Newbridge-on- Wye
Central Wales Cup
Knighton v Berriew
Carno v Bow Street
Bishops Castle v Llanfair
Montgomery v Llanidloes
Newscastle Em v Four Crosses
New Quay v Churchstoke
Radnor Valley v Llanrhaeadr
Waterloo v Presteigne
Dyffryn Banw v Brecon
Forden v Kerry (at Newtown)